Michael D Wiese Selected Research

Cytochrome P-450 Enzyme System (Cytochrome P450)

6/2022	Maternal-placental-fetal drug metabolism is altered by late gestation undernutrition in the pregnant ewe.
12/2021	Hepatic cytochrome P450 function is reduced by life-long Western diet consumption in guinea pig independent of birth weight.
11/2021	Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit.
1/2020	The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity.
7/2012	Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis.
7/2012	Systematic review and meta-analysis of the association between cytochrome P450 2C19 genotype and bleeding.

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Michael D Wiese Research Topics

Disease

21	Rheumatoid Arthritis 11/2023 - 07/2012
11	Hypersensitivity (Allergy) 01/2024 - 02/2004
6	Anaphylaxis (Anaphylactic Shock) 02/2022 - 03/2003
6	Drug-Related Side Effects and Adverse Reactions 01/2020 - 02/2014
6	Arthritis (Polyarthritis) 01/2016 - 07/2012
4	Bites and Stings (Sting) 02/2022 - 03/2003
3	Fetal Growth Retardation (Intrauterine Growth Retardation) 11/2023 - 01/2020
3	Fetal Weight 01/2023 - 01/2021
3	Chronic Pain 05/2022 - 04/2021
3	Inflammation (Inflammations) 01/2021 - 01/2020
3	Neoplasms (Cancer) 01/2020 - 01/2016
3	Colorectal Neoplasms (Colorectal Cancer) 10/2016 - 12/2015
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2023 - 01/2020
2	Malnutrition (Nutritional Deficiencies) 06/2022 - 10/2021
2	Frailty 05/2022 - 01/2021
2	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2020
2	Pain (Aches) 01/2020 - 01/2016
2	Psoriatic Arthritis 04/2015 - 03/2013
2	Multiple Sclerosis 08/2014 - 08/2013
1	Maternal Obesity 12/2023
1	Hypoglycemia (Reactive Hypoglycemia) 06/2022
1	Venom Hypersensitivity 02/2022
1	Pulmonary Hypertension 01/2022
1	COVID-19 01/2022
1	Acute Disease 01/2022
1	Secondary Hyperparathyroidism 01/2022
1	Chronic Renal Insufficiency 01/2022
1	Non-alcoholic Fatty Liver Disease 12/2021
1	Birth Weight (Birth Weights) 12/2021
1	Disease Progression 11/2021
1	Body Weight (Weight, Body) 09/2021
1	Acute Pain 09/2021
1	Dementia (Dementias) 01/2021
1	Sarcopenia 01/2021
1	Muscular Diseases (Myopathy) 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Obesity 10/2020
1	Neoplasm Metastasis (Metastasis) 01/2020
1	Osteoarthritis 01/2020
1	Osteoporosis 01/2020
1	Thrombocytopenia (Thrombopenia) 01/2020

Drug/Important Bio-Agent (IBA)

11	Antirheumatic Agents (DMARD)IBA 11/2021 - 07/2012
8	Ant VenomsIBA 01/2024 - 03/2003
8	Leflunomide (Arava)FDA LinkGeneric 01/2021 - 07/2012
7	Methotrexate (Mexate)FDA LinkGeneric 11/2023 - 04/2015
6	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 06/2022 - 07/2012
6	VenomsIBA 02/2022 - 02/2004
4	EnzymesIBA 06/2022 - 07/2012
3	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 06/2022 - 07/2012
3	Oxygen (Dioxygen)IBA 10/2021 - 01/2020
3	Opioid Analgesics (Opioids)IBA 09/2021 - 01/2020
3	Dihydroorotate DehydrogenaseIBA 01/2021 - 07/2012
3	teriflunomideIBA 01/2021 - 08/2013
3	Immunoglobulin E (IgE)IBA 01/2018 - 01/2011
3	Monoclonal AntibodiesIBA 01/2017 - 12/2015
2	Proteins (Proteins, Gene)FDA Link 01/2024 - 01/2018
2	ResveratrolIBA 01/2023 - 01/2021
2	Glucose (Dextrose)FDA LinkGeneric 06/2022 - 10/2021
2	VaccinesIBA 01/2022 - 01/2008
2	Biomarkers (Surrogate Marker)IBA 09/2017 - 12/2015
2	Cytochrome P-450 CYP2C19IBA 12/2014 - 12/2013
1	AndrogensIBA 12/2023
1	Fatty Acids (Saturated Fatty Acids)IBA 11/2023
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2023
1	tocilizumab (atlizumab)FDA Link 01/2023
1	Tramadol (K315)FDA LinkGeneric 05/2022
1	Arthropod VenomsIBA 02/2022
1	Sildenafil Citrate (Viagra)FDA Link 01/2022
1	Cholecalciferol (Vitamin D3)FDA Link 01/2022
1	Vitamin D3 24-HydroxylaseIBA 01/2022
1	Cytochrome P-450 CYP3AIBA 12/2021
1	Triglycerides (Triacylglycerol)IBA 12/2021
1	CholesterolIBA 12/2021
1	MicroRNAs (MicroRNA)IBA 11/2021
1	Cell-Free Nucleic AcidsIBA 11/2021
1	Surface-Active Agents (Surfactants)IBA 10/2021
1	Fentanyl (Sublimaze)FDA LinkGeneric 09/2021
1	Cytochrome P-450 CYP3A InhibitorsIBA 09/2021
1	CreatinineIBA 09/2021
1	LipopolysaccharidesIBA 01/2021
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021
1	Interleukin-1 Receptor-Associated KinasesIBA 05/2020
1	Trastuzumab (Herceptin)FDA Link 01/2020
1	Anesthetics (Anesthetic Agents)IBA 01/2020
1	NitrogenIBA 01/2020
1	Analgesics (Analgesic Drugs)IBA 01/2020
1	Ado-Trastuzumab EmtansineIBA 01/2020
1	taxaneIBA 01/2020
1	pertuzumabIBA 01/2020
1	GlucocorticoidsIBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	Propofol (Diprivan)FDA LinkGeneric 01/2020
1	Lapatinib (GW572016)FDA Link 01/2020

Therapy/Procedure

15	Therapeutics 01/2022 - 03/2013
4	Drug Therapy (Chemotherapy) 06/2017 - 08/2014
2	Polypharmacy 01/2021 - 02/2014
2	Deprescriptions 10/2014 - 02/2014
1	Enteral Nutrition (Feeding, Tube) 01/2021
1	Precision Medicine 01/2021
1	Anesthesia 01/2020